Visitors to the Tuli Area need to book beforehand, whether arriving as part of an organised tour or on a self-drive safari. There is a range of wildlife activities available over and above the usual game drives, including mountain bike, walking and horseback safaris. Underground hides at waterholes are popular with photographers. The wildlife in the area is generally well-habituated, with good populations of general game.

Of the Big 5, lion, leopard, elephant, and buffalo are regularly seen, with only rhinos absent. Good sightings of cheetahs and wild dogs are frequent. Offroad driving is permitted in Tuli, and bird-watching is best from November to April. Guests can stay at fully-catered lodges or simple self-catered bush camps. For self-drive, it is best to stock up on all provisions prior to arrival.